
What Drugs Cause Jaw Clenching, Teeth Grinding, & Bruxism?
Key Takeaways Some drugs and medications can cause bruxism—a condition where people grind their teeth or clench their jaw. Common culprits include methamphetamine, ecstasy, cocaine, and SSRIs (antidepressants). Long-term bruxism can lead to tooth damage, jaw pain, and sleep issues.